NEEDLE-FREE BUCCAL ANESTHESIA USING IONTOPHORESIS AND AMINO AMIDE SALTS COMBINED IN A MUCOADHESIVE FORMULATION
From web site Autors Camila Cubayachi, Ren锚 Oliveira do Couto, Cristiane Masetto de Gaitani, Vin铆cius Pedrazzi, Osvaldo de Freitas, Renata Fonseca Vianna Lopez ABSTRACT Iontophoresis is a strategy to increase the penetration of drugs through biological membranes; however, its use has been underexplored in mucosa. The aim of this work was to investigate the influence of iontophoresis in the mucosal penetration of prilocaine hydrochloride (PCL) and lidocaine hydrochloride (LCL), which are largely used in dentistry as local anesthetics, when combined in the same formulation. Semisolid hydrogels containing these drugs either alone or in combination were developed at two different pHs (7.0 and 5.8) and presented adequate mechanical and mucoadhesive properties for buccal administration. The distribution coefficients between the mucosa and the formulations ( D m/f ) and the in vitro mucosa permeation and retention rates were evaluate...