Persistent effects after trigeminal nerve proprioceptive stimulation by mandibular extension on rat blood pressure, heart rate and pial microcirculation.

The trigemino-cardiac reflex is a brainstem reflex known to lead to a decrement in heart rate and blood pressure, whereas few data have been collected about its effects on the cerebral hemodynamic.

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Device for cyclical extension of the jaw

WO 2011107875 A8

Inventors - Daniele Tonlorenzi - MARCELLO BRUNELLI

A device (1) for treating or preventing cerebral diseases, arterial hypertension, cerebral stroke, neurodegenerative diseases, provides a means for causing a mouth hyperextension and activating the proprioceptive sensations of the mandibular muscles. The means for causing a mouth hyperextension comprise a central portion (30) including a "U"- folded metal lamina of about 1-2 mm of thickness, for example 1.2 mm. At the end (31.32) of the central portion (30) are provided two curved laminar portions (10.20) that are arranged to be located, in use, at the upper wall (41) and at the lower wall (42) of the oral cavity of a patient (50). More in detail, the curved laminar portions (10.20) can be connected to the central portion (30) through a respective stair portion (11.21). This allows the central portion (30) to go beyond the dental arches (51, 52) of the patient (50), in order to arrange the laminar portions (10.20) adjacent to the palate and to the space between the tongue and the lower dental arch of the patient, or directly on the tongue itself. The metal of the device (1) has such a hardness that allows, in use, to stretch the mandibular elevator muscles.

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